Treatment strategy for advanced soft tissue sarcoma
نویسندگان
چکیده
منابع مشابه
Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib
Soft tissue sarcomas comprise approximately 1% of all adult solid malignancies. While chemotherapy is the mainstay of treatment for patients with metastatic or inoperable disease, overall survival for these patients is approximately 12 months, highlighting the need for novel agents. Both laboratory and clinical data have suggested that antiangiogenic agents may have a role in the treatment of s...
متن کاملManagement of Advanced Adult Soft Tissue Sarcoma
The rare incidence and heterogeneous nature of soft tissue sarcomas (STS) are formidable barriers to the conduct of large randomised controlled trials (RCTs). A search of computer databases, using a Cochrane optimal search strategy 1966–1996, yielded less than 100 RCTs investigating the management of bone and soft tissue sarcomas (Bramwell 1997, Proceedings 5th Annual Cochrane Colloquium – unpu...
متن کاملCurrent treatment of soft tissue sarcoma.
arcomas are rare tumors, representing only 0.8% of new cancers in the United States. Seventy-six percent arise in soft tissue, with the remainder arising in bone (1). The most common soft tissue type is malignant fibrous histiosarcoma, although this has fallen out of favor recently as a distinct histologic entity (2, 3). Multiple types of soft tissue sarcomas are defined based on the tissue of ...
متن کاملNeoadjuvant treatment of locally advanced soft tissue sarcoma of the limbs: which treatment to choose?
Soft tissue sarcomas (STSs) form a heterogeneous group of malignant neoplasms arising in the mesenchymal connective tissues. They can develop at any anatomic site but 60% occur in the extremities. Initially, treatment of STS relied solely on excision. In the 1970s, Enneking et al. developed the concept of compartmental resection to reduce the local failure rate. Later, Rosenberg et al. demonstr...
متن کاملOxaliplatin-dacarbazine combination chemotherapy for the treatment of advanced soft tissue sarcoma of the limbs
BACKGROUND This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb. PATIENTS AND METHODS Between November 2005 and November 2008, 31 patients with advanced limb STS classified with stage IV STS were randomly assigned into experimental or control gro...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2017
ISSN: 0923-7534
DOI: 10.1093/annonc/mdx569.001